Endocrine Abstracts

Liver and visceral ectopic fatty tissue disposition is a major metabolic derangement leading to type 2 diabetes, hypertension, dyslipidaemia, recapitulated in the metabolic syndrome (MetS). We have demonstrated that the selective FXR agonist obeticholic acid (OCA, INT-747) ameliorates the metabolic profile and reduces visceral adipose tissue (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS. We now report the effects of OCA treatment in HFD (0.5% cholesterol and 4% p...

Introduction: Adipose tissue dysfunction is associated to metabolic syndrome (MetS), a clustering of cardio-metaboilic risk factors, including hypogonadism. We recently demonstrated that T supplementation was able to ameliorate the metabolic profile and reduce visceral fat accumulation in high-fat diet (HFD)-induced rabbit model of MetS.Methods: We evaluated the differentiation capacity of preadipocytes (rPAD) obtained from visceral fat of the following ...